報告人: Laurence David Sibley
美國華盛頓大學教授，美國科學院院士
中國農業大學動物醫學院榮譽教授
時 間：2018年9月17日9:00-10:30
地 點：動醫動科大樓401會議室
聯系人：龍少軍
電 話：13651265229
L. David Sibley is the Alan A. and Edith L. Wolff Distinguished Professor in Molecular Microbiology at Washington University School of Medicine, St. Louis. Sibley is a recognized for his work on the cellular and molecular basis of intracellular parasitism and for defining the molecular determinants of pathogenesis that underlie diseases caused by protozoan parasites. Sibley was born in Philadelphia and grew up in Pennsylvania and Ohio. He earned a B.A. degree in biological sciences from Oberlin College in 1978, and a PhD in zoology and physiology from Louisiana State University in 1985. He completed postdoctoral fellowships at the U.S. Public Health Service’s National Hansen’s Disease Center and Stanford University School of Medicine. In 1991, Sibley joined the faculty in the Department of Molecular Microbiology at Washington University School of Medicine, St. Louis. He is a Burroughs-Wellcome Scholar in Molecular Parasitology (2000-2005), a recipient of the Alice and CC Wang Molecular Parasitology Award from the American Society of Biochemistry and Molecular Biology (2017), and a Fellow in the American Academy of Microbiology (2007).
Research Interests
My research program is focused on defining adaptations that enable intracellular parasites to gain entry into their host cells, avoid host defenses, and establish a replicative niche. Using Toxoplasma gondii as a model system, we have defined parasite-mediated mechanisms that control host-cell entry and egress, and that mediate tissue migration during parasite dissemination in the host. Together with an extensive group of international collaborators, we have explored genetic diversity and defined the global population structure of this widespread parasite of warm-blooded vertebrates including humans. We have developed a variety of genetic strategies to compare phenotypic differences between natural isolates and to define the molecular basis of pathogenesis. These studies demonstrate that pathogenesis determinants act by altering host gene expression, blocking signaling pathways, and subverting immune responses. Our findings have uncovered novel and essential aspects of parasite biology that provide opportunities for developing new therapies for animal and human diseases.
Web page：http://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=2882
Awards and Honors
1982 - 1985 Louisiana State University Alumni Federation Predoctoral Fellowship
1988 - 1991 Merck Postdoctoral Fellowship, Stanford University
1993 - 1997 Burroughs Wellcome Fund New Investigator Award in Molecular Parasitology
1999 - 2000 Excellence in Mentoring Award, Graduate Student Senate, Washington University
2000 - 2005 Burroughs Wellcome Fund Scholar Award in Molecular Parasitology
2004 - 2005 Excellence in Mentoring Award, Graduate Student Senate, Washington University
2006 - Alan Kaplan Lecture, University of Kentucky
2007 - Fellow, American Academy of Microbiology
2007 - Division AA Lecturer, American Society of Microbiology
2008 - Molecular, Cellular, and Immunoparasitology Scientific Excellence Award, American Society of Tropical Medicine and Hygiene
2011 - Howard T. Ricketts Lecture, University of Chicago
2011 - 2012 Distinguished Investigator Award, Washington University School of Medicine
2012 - Norman D. Levine Lecture, University of Illinois
2012 - 2013 Excellence in Mentoring Award, Graduate Student Senate, Washington University
2012 - Bruce A.D. Stocker Lecture, Stanford University School of Medicine
2014 Aikawa Memorial Lecture, Case Western Reserve University
2014 Thomson Reuters ISI Highly Cited Researchers List in Microbiology
2017 Alice and C.C. Wang Award In Parasitology, American Society for Biochemistry and Molecular Biology
2017 Member, National Academy of Science
